ea0029p497 | Developmental endocrinology | ICEECE2012
Ben-Skowronek I.
, Drabko K.
, Wojcik B.
, Kowalczyk J.
Introduction: Endocrinologic dysfunction is a well-known complication after hematopoietic stem cell transplantation (HSCT) in children. The mechanisms of thyroid damage developing after transplantation remain not completely recognized. Toxicity of the conditioning regimen, especially total body irradiation, is most commonly postulated cause of endocrine abnormalities; immunological mechanisms (e.g. graft vs host disease) may also contribute to thyroid dysfunction.<p class=...